Table 3.
Correlation between Srx, PROX1 and Nrf2 levels in the studied gastric cancer patients and their demographic and histopathological parameters
| Parameter | Srx level | p-value# | PROX1 | p-value# | Nrf2 | p-value# | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low n = 21 (42%) |
High n = 29 (58%) |
Low n = 28 (56%) |
High n = 22 (44%) |
Low n = 21 (42%) |
High n = 29 (58%) |
|||||
| Gender | 0.724 | 0.856 | 0.097 | |||||||
| Male | 15 (71.4) | 22 (75.9) | 21 (75) | 16 (72.7) | 13 (61.9) | 24 (82.8) | ||||
| Female | 6 (28.6) | 7 (24.1) | 7 (25) | 6 (27.3) | 8 (38.1) | 5 (17.2) | ||||
| Age group | 0.432 | 0.558 | 0.044* | |||||||
| < 60 years | 8 (38.1) | 8 (27.6) | 8 (28.6) | 8 (36.4) | 10 (47.6) | 6 (20.7) | ||||
| ≥ 60 years | 13 (61.9) | 21 (72.4) | 20 (71.4) | 14 (63.6) | 11 (52.4) | 23 (79.3) | ||||
| Initial site | 0.074 | 0.084 | 0.416 | |||||||
| Proximal | 13 (61.9) | 11 (37.9) | 11 (39.3) | 13 (59.1) | 12 (57.1) | 12 (41.4) | ||||
| Distal | 8 (38.1) | 13 (44.8) | 12 (42.9) | 9 (40.9) | 8 (38.1) | 13 (44.8) | ||||
| Diffuse | 0 (0) | 5 (17.2) | 5 (17.9) | 0 (0) | 1 (4.8) | 4 (13.8) | ||||
| Histopathology | 0.066 | 0.059 | 0.383 | |||||||
| Intestinal | 21 (100) | 24 (82.8) | 23 (82.1) | 22 (100) | 20 (95.2) | 25 (86.2) | ||||
| Diffuse | 0 (0) | 5 (17.2) | 5 (17.9) | 0 (0) | 1 (4.8) | 4 (13.8) | ||||
| Size | 0.310 | 0.449 | 0.391 | |||||||
| < 5 cm | 11 (52.4) | 11 (37.9) | 11 (39.3) | 11 (50) | 11 (52.4) | 11 (37.9) | ||||
| ≥ 5 cm | 10 (47.6) | 18 (62.1) | 17 (60.7) | 11 (50) | 10 (47.6) | 18 (62.1) | ||||
| Grade | 0.006* | 0.005* | 0.031* | |||||||
| Low | 10 (47.6) | 6 (20.7) | 6 (21.4) | 10 (45.5) | 10 (47.6) | 6 (20.7) | ||||
| Intermediate | 11 (52.4) | 13 (44.8) | 12 (42.9) | 12 (54.5) | 10 (47.6) | 14 (48.3) | ||||
| High | 0 (0) | 10 (34.5) | 10 (35.7) | 0 (0) | 1 (4.8) | 9 (31) | ||||
| T | 0.001** | 0.005* | 0.001** | |||||||
| T1b | 7 (33.3) | 2 (6.9) | 2 (7.1) | 7 (31.8) | 7 (33.3) | 2 (6.9) | ||||
| T2 | 6 (28.6) | 1 (3.4) | 1 (3.6) | 6 (27.3) | 6 (28.6) | 1 (3.4) | ||||
| T3 | 3 (14.3) | 4 (13.8) | 4 (14.3) | 3 (13.6) | 4 (19) | 3 (10.3) | ||||
| T4a | 4 (19) | 9 (31) | 9 (32.1) | 4 (18.2) | 2 (9.5) | 11 (37.9) | ||||
| T4b | 1 (4.8) | 13 (44.8) | 12 (42.9) | 2 (9.1) | 2 (9.5) | 12 (41.4) | ||||
| N | 0.04 | 0.023* | 0.56 | |||||||
| N0 | 9 (42.9) | 4 (13.8) | 3 (10.7) | 10 (45.5) | 7 (33.3) | 6 (20.7) | ||||
| N1 | 6 (28.6) | 6 (20.7) | 6 (21.6) | 6 (27.3) | 6 (28.6) | 6 (20.7) | ||||
| N2 | 4 (19) | 8 (27.6) | 8 (28.6) | 4 (18.2) | 5 (23.8) | 7 (24.1) | ||||
| N3 | 2 (9.5) | 11 (24.1) | 11 (25) | 2 (9.1) | 3 (9.5) | 10 (24.1) | ||||
| M | 0.129 | 0.121 | 0.63 | |||||||
| Absent | 21 (100) | 25 (86.2) | 24 (85.7) | 28 (100) | 20 (95,2) | 26 (88.7) | ||||
| Present | 0 (0) | 4 (13.8) | 4 (14.3) | 0 (0) | 1 (4.8) | 3 (11.3) | ||||
| Stage | 0.001** | 0.003* | 0.02* | |||||||
| 1A | 4 (19) | 0 (0) | 0 (0) | 4 (18.2) | 4 (19) | 0 (0) | ||||
| 1B | 4 (19) | 2 (6.9) | 2 (7.1) | 4 (18.2) | 4 (19) | 2 (6.9) | ||||
| IIA | 4 (19) | 1 (3.4) | 1 (3.6) | 4 (18.2) | 4 (19) | 1 (3.4) | ||||
| IIB | 5 (23.8) | 1 (3.4) | 1 (3.6) | 5 (22.7) | 3 (14.3) | 3 (10.3) | ||||
| IIIA | 1 (4.8) | 1 (3.4) | 4 (14.3) | 1 (4.5) | 2 (9.5) | 3 (10.3) | ||||
| IIIB | 2 (9.5) | 4 (13.8) | 9 (32.1) | 3 (13.6) | 2 (9.5) | 10 (34.5) | ||||
| IIIC | 2 (9.5) | 10 (34.5) | 7 (25) | 1 (4.5) | 1(4.8) | 7 (21.4) | ||||
| IV | 0 (0) | 4 (13.8) | 4 (14.3) | 0 (0) | 1 (4.8) | 3 (10.3) | ||||
*
p < 0.05 is statistically significant, # χ2 test, ** p ≤ 0.001 is statistically highly significant