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. 2021 Jan 18;21(3):211. doi: 10.3892/ol.2021.12472

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — MCM3AP-AS1 overexpression enhances CDDP resistance in GC cells. (A) The overexpression efficiency of MCM3AP-AS1 in NCI-N87/CDDP and AGS/CDDP cells was assessed by reverse transcription-quantitative PCR. (B) Migratory (magnification, ×200) and (C) invasive abilities (magnification, ×200) of CDDP-resistant GC cells was detected after overexpressing MCM3AP-AS1 by wound healing and Transwell assays, respectively. (D) Cell viability of NCI-N87/CDDP and AGS/CDDP cells was measured after overexpressing MCM3AP-AS1 by Cell Counting Kit-8 assay. (E) The IC₅₀ of NCI-N87/CDDP and AGS/CDDP cells was tested after overexpressing MCM3AP-AS1 by drug-sensitivity assay. *P<0.05 vs. pcDNA3.1. MCM3AP-AS1, MCM3AP antisense RNA 1; CDDP, cisplatin; GC, gastric cancer; OD, optical density.