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. 2021 Jan 16;2(4):411–422.e5. doi: 10.1016/j.medj.2021.01.001

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High-Frequency sample collection cohort at UCSF

(A and B) Patient-specific relative tissue contributions for SARS-CoV-2 patients (A) and other RNA virus infection patients (B). Triangles (A) indicate sampling times and the star (B) represents the erythroblast fraction of an influenza B patient who was being treated for recurrent stage IV diffuse large B cell lymphoma.

(C) Heatmaps of Bray-Curtis dissimilarity.

(D) Scatterplot of patient-specific Bray-Curtis dissimilarity (left) and boxplot of Bray-Curtis dissimilarity between cfDNA tissue proportions from samples collected from either the same day (within 24 h), the same person (but not within 24 h), or from all of the patients (right).

(E) Comparison of tissue fraction of 4 cell and tissue types (neutrophil, erythroblast, lung, and liver) between SARS-CoV-2-positive patients and other RNA virus-positive patients. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 (p values calculated using a Wilcoxon test)