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. 2021 Jan 25;12:87. doi: 10.1186/s13287-021-02161-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Rats were divided into 4 groups: sham, CIH exposure, CIH + exosomes from untreated ADSCs (Exo), and CIH + miR-301a-3p-enriched exosomes (Exo-301a). a, b Results of Masson trichrome staining for actin (red) and collagen (blue). c, d Results of Phalloidin (green) and DAPI (blue) staining in SD rats. e The purple rectangle denotes the area of the penis selected for an area for histology analysis. f Protein levels of α-SMA in sham, CIH, CIH+EXO, and CIH+EXO-301a groups as determined by Western blotting. g, h Results of ICP and RT-AP measurement in all four groups. The ICP is indicated with a green curve. The red curve denotes the real-time AP during electrostimulation. The orange bar denotes the 60-s cavernous nerve electrical stimulation. Data are expressed as mean ± SD (n = 6; ***p < 0.001)