Table 1.

Association of miR-146a downregulation/deficiency with vascular and autoimmune diseases.

Expression/Function	Association with pathological condition/disease	Reference
Human
Downregulation of plasma miR-146a	Poor coronary collateral circulation in patients with coronary artery disease	[31]
Downregulation of serum miR-146a	Severe acute ischemic stroke	[32]
Downregulation of serum miR-146a	Acute exacerbation of chronic obstructive pulmonary disease and negative correlation with inflammatory cytokines: TNF-α, IL-1β, IL-6, IL-8	[33]
Downregulation of PBMCs-derived miR-146a	Severe systemic lupus erythematosus and the induction of type I IFNs	[34]
miR-146a-deficient mice
Knockout of the miR-146a gene in C57BL/6 mice	Myeloproliferative disease (myeloid and lymphoid malignancies) due to a lack of NF-kB suppression	[35]
Mice harboring miR-146a-deficient Treg cells	Impaired function of Treg cells: no restraint of IFN-γ-mediated pathogenic Th1 responses and associated inflammation	[36]
Model of myocardial ischemia and reperfusion injury	Decreased heart function and increased myocardial infarction and apoptosis by targeting Med 1 gene	[37]
Model of Atopic dermatitis	Increased accumulation of infiltrating cells in the dermis, elevated expression of IFN-γ, CCL5 and CCL8 in the skin	[38]