Table 1.

Comparison of the effects of 50 μM CA-074 Me, 50 μM CA-074 and 100 μM E64d on the relative abundances of different Aβ peptide variants in supernatants of H4 cells, H4 APP 751 cells, H4 APP 751 CTSB –/– cells, chicken astrocytes, and human astrocytes compared to controls.

H4APP 751/(H4)	Aβ1−40	Aβ1−42	Aβ2−40
CA-074 Me (50 μM)	↑↑/(↑)	↑↑	↓
CA-074 (50 μM)	↔	↔	↓
H4APP 751 CTSB–/–	Aβ1−40	Aβ1−42	Aβ2−40
CA-074 Me (50 μM)	↔	↔	↔
Chicken astrocytes/(Human astrocytes)	Aβ1−40	Aβ1−42	Aβ2−40
E64d	↔	↑	↓↓
CA-074 Me	↔/(↔)	↔/(↔)	↓↓/(↓↓*)

The decrease of Aβ 2-40 in supernatants from human astrocytes after CA-074 Me treatment has to be considered as preliminary (n = 2, *).

x-fold increase: ↑↑ $\underset{\_}{\underset{\_}{\wedge }}$ x > 200%; ↑ $\underset{\_}{\underset{\_}{\wedge }}$ 125% < x <200%, ↔ $\underset{\_}{\underset{\_}{\wedge }}$ 75% < x < 125%; ↓ $\underset{\_}{\underset{\_}{\wedge }}$ 50% < x < 75%; ↓↓ $\underset{\_}{\underset{\_}{\wedge }}$ 10% < x < 50%.