Figure 2.

Landscape of genomic variants

A. Number of mutations in different mutation types. The orange bar indicates the number of all mutations, and the blue bar indicates the number of mutations with PMF > 0.001. B. 3D structure display for nonsynonymous mutations in S protein (PDB: 6VSB, http://www.rcsb.org/structure/6VSB). The structure is shown in sphere (left panel) and stick (right panel). The three chains (A, B, and C) of S protein are displayed in blue, yellow, and green, respectively. The binding region (amino acid residues: 336–516) of the S protein with its receptor human ACE2 is shown in cyan for all three chains. C. Pie chart showing variant annotation for each gene of SARS-CoV-2. D. Distribution of PMF for all variants. Coordinate information for representative variants (including positions 241, 1059, 3037, 8782, 14408, and 23403) is provided. PMF, population mutation frequency; ACE2, angiotensin-converting enzyme 2.