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. 2020 Dec 15;184(2):476–488.e11. doi: 10.1016/j.cell.2020.12.015

Figure 4.

Figure 4

Neutralization potency correlates with distinct serum cytokine signatures in severe versus non-severe cases of COVID-19

(A) Serum cytokines were measured in COVID-19 patients that were non-hospitalized (n = 15), hospitalized (n = 38), intubated (n = 23), deceased (n = 9), and immunosuppressed (n = 13), and the average cytokine level for each cohort was calculated and presented as a heatmap. Color scales are normalized to each cytokine (column).

(B and C) A multivariate analysis was performed to calculate pairwise correlations between anti-RBD IgG neutralization potency index (NT50/IgG) and serum cytokine levels in non-severe (n = 61; upper panel) and severe cases of COVID-19 (n = 37; lower panel). Severe cases were defined as ones requiring intubation or resulting in death, and non-severe cases were all others (without accounting for immunosuppression status). Error bars indicate 95% confidence intervals and unadjusted p values are indicated as follows: ∗∗p < 0.01, p = 0.05.

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