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. 2020 Nov 27;3(1):vdaa162. doi: 10.1093/noajnl/vdaa162

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Glycolytic expression is associated with an elevated LDHA/LDHB ratio and decreased LDHA promoter methylation. (A) Boxplots showing a significantly elevated LDHA/LDHB ratio in the glycolytic-high cluster (cluster1) for the discovery set (P = 4.62e−15). (B) Boxplots showing a significantly elevated LDHA/LDHB ratio in the glycolytic-high cluster (cluster2) for the validation set (P < 0.0001). (C,D) The level of LDHA promoter methylation was also inversely associated with the LDHA/LDHB ratio in both the discovery set (C) (r = −0.78, P = 2.69e−52) and the validation set (D) (r = −0.77, P = 2.25e−51).