Figure 3.

Number of GzmB⁺ (A) and CD8⁺ cells (B) in study subjects with FEV₁ below 80% predicted and those with FEV₁ 80% or above in CLE subjects. (A) Significantly higher number of alveolar GzmB⁺ cells in subjects with FEV₁ 80% or above than those with FEV₁ below 80% in CLE subjects. (B) No difference in number of alveolar CD8⁺ cells between the two groups. Correlations between number of alveolar GzmB⁺ cells and volume fraction of those cells in small airway wall (C) and correlations between number of alveolar CD8⁺ cells and volume fraction of those cells in small airway wall (D) in CLE subjects. (C) Positive relationship between number of alveolar GzmB⁺ cells and volume fraction of those cells in small airway wall, suggesting common associated role of GzmB⁺ cells in emphysema and small airway disease in CLE subjects. (D) No relationship between number of alveolar CD8⁺ cells and volume fraction of those cells in small airway wall. CLE: centrilobular emphysema; FEV₁: postbronchodilator forced expiratory volume in 1 second; GzmB: granzyme B; Vv: volume fraction.