Table 2.
Morphometric characteristics of lung tissues of study subjects
| Nonsmoker control | PLE | CLE | p-value | |
|---|---|---|---|---|
| No. of subjects | 12 | 12 | 30 | |
| Lm, mm | 0.191±0.046* | 0.275±0.095 | 0.274±0.055 | 0.002 |
| CV of IAWD | 0.281±0.068 | 0.319±0.182 | 0.517±0.198† | 0.001 |
| Airway wall thickness, mm | 0.063±0.017 | 0.079±0.029 | 0.093±0.021‡ | 0.002 |
| Small airway wall | ||||
| Vv of CD8+ cells, % | 1.09±0.47 | 1.32±0.46 | 2.14±0.50 | 0.001 |
| Vv of GzmB+ cells, % | 1.26±0.60 | 1.24±0.65 | 2.74±1.10 | 0.001 |
| Alveolar wall | ||||
| CD8+ cells/mm | 1.69±1.59 | 2.03±2.76 | 7.70±3.37§ | 0.001 |
| GzmB+ cells/mm | 2.97±2.91 | 2.69±3.05 | 5.18±3.39‖ | 0.016 |
Values are presented as mean±SD.
*
p<0.03 vs. PLE and CLE subjects.
†
p<0.005 vs. control and PLE subjects.
‡
p<0.001 vs. control subjects.
§
p<0.001 vs. control and PLE subjects.
‖
p<0.05 vs. control and PLE subjects.
PLE: panlobular emphysema; CLE: centrilobular emphysema; Lm: mean linear intercept; CV: coefficient of variation; IAWD: interalveolar wall distance; Vv: volume fraction; GzmB: granzyme B.