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. 2020 Oct 8;83(Supple 1):S63–S74. doi: 10.4046/trd.2020.0112

Figure 5.

Figure 5.

The effects of bleomycin (BLE), chronic intermittent hypoxia (CIH), and pirfenidone (PF) on lung fibrosis. (A) Representative photomicrographs of lung tissues were stained with Masson’s trichrome stain as a measure of collagen accumulation. The upper panels show images of whole lung sections, and the bottom panels represent the enlarged images. Scale bars=2,000 μm, middle panels (×10); 100 μm, bottom panels (×200). (B) Sirius red staining (×200). (C) Hydroxyproline content was measured in lung tissues. (D) Serum transforming growth factor β (TGF-β) levels were measured by performing enzyme-linked immunosorbent assays. The data shown are expressed as the mean±SD. *p<0.05, **p<0.01, ***p<0.001 vs. the CIH+BLE group. p<0.05, ††p<0.01 vs. the normoxia (NOR)+BLE group.