Table 3.
Clinical risk factors associated with mortality
| Variable | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Age, yr | 1.05 | 1.03–1.08 | <0.001 | - | - | - |
| 18–40 | 0.12 | 0.04–0.35 | <0.001 | 0.06 | 0.01–0.54 | 0.012 |
| >65 | 3.44 | 1.81–6.56 | <0.001 | - | - | - |
| ≥55 vs. <55 | 3.59 | 1.94–6.61 | <0.001 | - | - | - |
| Days from symptom onset to admission (<7 vs. ≥7) | 1.16 | 1.05–1.28 | 0.004 | - | - | - |
| Dyspnea mMRC (≥3 vs. <3) | 5.73 | 2.67–12.32 | <0.001 | 3.59 | 1.51–8.52 | 0.004 |
| Chest pain (yes vs. no) | 0.47 | 0.26–0.87 | 0.016 | - | - | - |
| Anosmia (yes vs. no) | 0.13 | 0.03–0.56 | 0.006 | - | - | - |
| Ageusia (yes vs. no) | 0.25 | 0.07–0.87 | 0.029 | - | - | - |
| Myalgias/artralgia (yes vs. no) | 0.52 | 0.29–0.92 | 0.026 | - | - | - |
| Respiratory rate (≥30 bpm vs. <30 bpm) | 4.95 | 1.38–17.75 | 0.014 | - | - | - |
| Heart rate (≥100 BPM vs. <100 BPM) | 1.82 | 0.99–3.32 | 0.052 | - | - | - |
| SpO2/FiO2 (<420 vs. ≥420) | 7.32 | 3.52–15.22 | <0.001 | 6.44 | 2.33–17.83 | 0.003 |
| qSOFA score (≥2 points vs. <2 points) | 6.08 | 2.54–14.56 | <0.001 | 3.46 | 1.04–11.58 | 0.044 |
| Invasive mechanical ventilation (yes vs. no) | 81.60 | 30.19–220.52 | <0.001 | 64.7 | 15.20–275.39 | <0.001 |
OR: odds ratio; CI: confidence interval; mMRC: modified Medical Research Council; bpm: breaths per minute; BPM: beats per minute; SpO2/FiO2: pulse oximetric saturation/fraction of inspired oxygen; qSOFA: quick Sequential Organ Failure Assessment.