Table 4.
Laboratory value risk factors associated with mortality
| Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Hematological and inflammation-related indices | ||||||
| White-cell count (≥12×103/µL vs. <12×103/µL) | 4.23 | 2.29–7.84 | <0.001 | - | - | - |
| Neutrophil count (≥10×103/µL vs. <10×103/µL) | 4.68 | 2.51–8.71 | <0.001 | - | - | - |
| Neutrophil-to-lymphocyte ratio (≥9 vs. <9) | 5.69 | 3.01–10.76 | <0.001 | 4.64 | 2.05–10.53 | <0.001 |
| Procalcitonin (≥0.5 ng/mL vs. <0.5 ng/mL) | 6.16 | 3.13–12.09 | <0.001 | - | - | - |
| CRP (≥150 mg/L vs. <150 mg/L) | 1.85 | 1.03–3.35 | 0.041 | - | - | - |
| Lymphocyte-to-CRP (<6 vs. ≥6) | 0.97 | 0.95–0.99 | 0.013 | - | - | - |
| Coagulation factors | ||||||
| D-dimer baseline (≥700 ng/mL vs. <700 ng/mL) | 2.64 | 1.44–4.84 | 0.002 | - | - | - |
| D-dimer day 3 (≥1,000 ng/mL vs. <1,000 ng/mL) | 4.69 | 2.28–9.65 | <0.001 | - | - | - |
| Organ-injury biochemical biomarkers | ||||||
| Glucose (≥130 mg/dL vs. <130 mg/dL) | 2.58 | 1.42–4.72 | 0.002 | - | - | - |
| Protein level (<6.5 g/dL vs. ≥6.5 g/dL) | 5.04 | 2.43–10.47 | <0.001 | - | - | - |
| Serum albumin (<3.5g/dL vs. ≥3.5 g/dL) | 4.62 | 2.14–9.95 | <0.001 | 3.76 | 1.56–9.07 | 0.003 |
| Troponin T (≥10 pg/mL vs. <10 pg/mL) | 6.30 | 3.30–12.05 | <0.001 | - | - | - |
| CK-MB (≥25 U/L vs. <25 U/L) | 3.17 | 1.72–5.83 | <0.001 | - | - | - |
| LDH (≥725 U/L vs. <725 U/L) | 5.85 | 3.03–11.27 | 0.004 | 5.45 | 2.36–12.57 | <0.001 |
OR: odds ratio; CI: confidence interval; CRP: C-reactive protein; CK-MB: creatine kinase mb fraction; LDH: lactate dehydrogenase.