Table 1.

Demographic and clinical characteristics of the DCR and NHANES cohorts.

	DCR	NHANES
	N=67433	N=21479573*
	Mean ± SD / %	Mean ± SD / %	p value	SMD†
Age (years)	61 ± 10	57 ± 12	<0.001	0.38
Sex (male)	52	56	<0.001	0.08
Race
White non-Hispanic	83	76	<0.001	0.30
Black non-Hispanic	14	15
Other	3	9
Insurance coverage	100	91	<0.001	0.42
Height (cm)	170 ± 11	168 ± 10	0.08	0.18
Weight (kg)	97 ± 24	94 ± 23	0.22	0.12
Body mass index (kg/m2)	33.3 ± 7.3	33.2 ± 7.6	0.96	0.05
Body mass index category
Underweight (<18.5 kg/m2)	0.5	0.5	<0.001	0.03
Normal (18.5–24.9 kg/m2)	9	10
Overweight (25–29.9 kg/m2)	26	26
Obese (≥30 kg/m2)	65	64
HbA1c (%)	7.5 ± 2.2	7.4 ± 1.8	0.60	0.03
HbA1c (mmol/mol)	58.1 ± 24.4	57.3 ± 20.0	0.60	0.03
HbA1c category			<0.001	0.16
<7% (<53 mmol/mol)	56	51
7–9% (53–75 mmol/mol)	27	35
>9% (>75 mmol/mol)	16	15
Systolic blood pressure (mmHg)	130 ± 17	129 ± 19	0.29	0.08
Diastolic blood pressure (mmHg)	76 ± 10	70 ± 13	<0.001	0.58
Blood pressure< 140/90 mmHG	70	74	<0.001	0.09
Total cholesterol (mmol/L)	4.45 ± 1.09	4.66 ± 1.17	0.050	0.18
High density lipoprotein (mmol/L)	1.22 ± 0.39	1.24 ± 0.39	0.73	0.03
Low density lipoprotein (mmol/L)	2.43 ± 0.91	3.34 ± 2.38	<0.001	0.50
Triglycerides (mmol/L)	1.81 ± 1.07	2.21 ± 1.63	0.007	0.29
Low density lipoprotein<2.59 mmol/L	61	41	<0.001	0.39
‘ABC’ control††	18.8	6.0	<0.001	0.40
Tobacco use	17	32	<0.001	0.35
Hypertension	81	66	<0.001	0.37
Dyslipidaemia	83	63	<0.001	0.48
Medication Use
Insulin	18	27	<0.001	0.22
Oral hypoglycaemic agent	56	71	<0.001	0.33
Cholesterol-lowering	71	67	<0.001	0.08
Anti-hypertensive	79	95	<0.001	0.50

^*Weighted sample size

^†Standardized mean difference

^††HbA1c<7% (<53 mmol/mol), blood pressure <140/90 mmHg and low density lipoprotein <2.59 mmol/L