Table 7.
BP-assodated effects on terminal body weights and liver weights in F0, F1cNP, and F1cP male and female rats.
| Endpoint | Generation | 0 ppm | 5000 ppm | 15,000 ppm | 40,000 ppm |
|---|---|---|---|---|---|
| Males | |||||
| No. Examined (Litters) | F0 | 20 | 21 | 21 | 22 |
| F1cNP | 43 (16) | 34 (12) | 46 (18) | 6 (5)a | |
| F1cP | 39 (19) | 37 (13) | 39 (18) | 26 (7) | |
| Terminal Body Weight (g) | F0 | 503.6 ± 6.6** | 497.6 ± 7.1 | 476.7 ± 5.0 | 448.8 ± 5.5 |
| F1cNP | 386.0 ± 9.4** | 388.1 ± 6.5 | 356.4 ± 6.1** | 298.1 ± 16.0** | |
| F1cP | 511.1 ± 9.5** | 504.7 ± 5.3 | 474.1 ± 8.8** | 409.8 ± 6.5** | |
| Liver Absolute (g) | F0 | 18.84 ± 0.36* | 19.27 ± 0.36 | 18.84 ± 0.52 | 17.85 ± 0.35 |
| F1cNP | 16.58 ± 0.53** | 17.23 ± 0.37 | 16.05 ± 0.34 | 14.52 ± 0.83 | |
| F1cP | 20.79 ± 0.56** | 20.71 ± 0.54 | 19.21 ± 0.41* | 17.77 ± 0.34** | |
| Liver Relative (mg/g)b | F0 | 37.40 ± 0.44** | 38.76 ± 0.60 | 39.48 ± 0.92* | 39.75 ± 0.51* |
| F1cNP | 42.83 ± 0.49** | 44.38 ± 0.70 | 45.03 ± 0.59* | 48.67 ± 0.82** | |
| F1cP | 40.63 ± 0.64* | 41.02 ± 0.93 | 40.75 ± 0.54 | 43.36 ± 0.53* | |
| Females | |||||
| No. Examined (Litters) | F0 | 21 | 18 | 21 | 22 |
| F1cNP | 39 (17) | 35 (14) | 41 (15) | —a | |
| F1cP | 27 (18) | 30 (14) | 30 (17) | 24 (8) | |
| Terminal Body Weight (g) | F0 | 297.1 ± 4.6** | 297.8 ± 3.7 | 288.7 ± 2.8 | 286.5 ± 3.5* |
| F1cNP | 258.2 ± 3.7** | 252.1 ± 5.4 | 230.3 ± 5.3** | — | |
| F1cP | 356.5 ± 4.9** | 356.0 ± 5.8 | 340.7 ± 6.5 | 293.9 ± 11.4** | |
| Liver Absolute (g) | F0 | 10.17 ± 0.21 | 10.59 ± 0.21 | 10.23 ± 0.20 | 10.66 ± 0.27 |
| F1cNP | 10.56 ± 0.27 | 10.81 ± 0.28 | 10.03 ± 0.39 | — | |
| F1cP | 17.31 ± 0.29 | 18.11 ± 0.48 | 18.02 ± 0.45 | 17.00 ± 0.99 | |
| Liver Relative (mg/g)b | F0 | 34.19 ± 0.34 ** | 35.53 ± 0.40 | 35.44 ± 0.57 | 37.13 ± 0.63 ** |
| F1cNP | 40.79 ± 0.61 * | 42.83 ± 0.59 | 43.42 ± 0.98 * | — | |
| F1cP | 48.59 ± 0.60 ** | 50.98 ± 1.32 | 52.93 ± 1.19 * | 57.60 ± 1.53 ** |
Statistical analysis for F0 animals performed by Jonckheere (trend) and Williams or Dunnett (pairwise) tests. Statistical analysis for F1 animals was performed by linear mixed models, with dam ID as random effect, and using Dunnett-Hsu adjustment, for both trend and pairwise analyses. Statistical significance for the control group indicates a significant trend test. Statistical significance for a treatment group indicates a significant pairwise test compared to the control group.
Data presented as average ± SEM.
Statistically significant at p ≤ 0.05;
p ≤ 0.01.
Reduced numbers of animals were evaluated in this group due to pup loss related to failure to thrive postweaning.
Relative organ weights (mg) normalized to terminal body weight (g).