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. Author manuscript; available in PMC: 2021 Jan 26.
Published in final edited form as: Cell Rep. 2021 Jan 5;34(1):108522. doi: 10.1016/j.celrep.2020.108522

Figure 7. Piwil1 Knockdown Reduces Tumor Growth and Improves Animal Survival.

Figure 7.

(A) Kaplan-Meier survival curve of mice implanted with 4121 or 3832 GSCs transduced with shNT or shPiwil1 shRNAs (n = 12 mice for each group).

(B) Immunofluorescence staining of Piwil1 and cleaved caspase 3 in shNT and shPiwil1 mice. Representative data from 3832 GSC-derived xenografts are shown. Nuclei were counterstained with DAPI (blue).

(C) Immunofluorescence staining of BTG2, FBXW7, and MCL1 in shNT and shPiwil1 mice. Representative data from 3832 GSC-derived xenografts are shown. Nuclei were counterstained with DAPI (blue).

****p < 0.0001.