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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Sep 7;1868(1):118847. doi: 10.1016/j.bbamcr.2020.118847

Figure 2.

Figure 2.

Domain structures of Class II Grxs from bacteria (Escherichia coli), trypanosomes (Trypanosoma brucei), yeast (Saccharomyces cerevisiae), plants (Arabidopsis thaliana), and mammals (Homo sapiens). The conserved cysteines in the Trx and Grx domains are shown in red. Additional conserved residues are shown in black. In eukaryotes, mitochondrial CGFS Grxs are single domain while cytosolic versions are multi-domain. Plants additionally have both single and multi-domain CGFS Grxs located in the chloroplast. Please note that the active site motifs of both cytosolic and mitochondrial Class II Grxs from trypanosomes (CAYS and CGFT) deviate from the canonical CGFS motif [117].