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Counter-testing of the GoC model obtained by switch-off of ionic channels in specific model sections. (A) Effect on basal firing of the switch-off of Cav2.2, Kca2.2, Kca1.1, Cav2.3, Cav3.1. These simulations imitate the experiments on pharmacological block reported in [14]. (B) Effect on the responses to negative currents steps (during the step and in the rebound phase) of the switch-off of HCN (HCN1 and HCN2) and Cav3.1.
