Table 1. Ionic mechanisms in the GoC model.
The table shows the main properties of ionic channels used in the Golgi cell models. For each ionic channel type, the columns specify the maximum ionic conductance Gi-max (value of the model in Fig 1 along with the range of parameters in the 8 models), ionic channels reversal potential Erev, the type of ionic channel mathematical representation and the reference from which the ionic channel gating equations have been taken, Markovian or Hodgkin-Huxley (HH).
| Type | Location | Gi-max (S/cm2) | Erev (mV) | Type of ionic Channel model | Reference |
|---|---|---|---|---|---|
| Na CHANNEL | |||||
| Nav1.6 | Apical Dendrites | 0.0049 (0.0024–0.0068) |
60 | Markovian | [47,57,58] |
| Basal Dendrites | 0.008 (0.006–0.00135) |
||||
| Soma | 0.149 (0.143–0.24) |
||||
| AIS | 0.172 (0.17–0.2) |
||||
| Axon | 0.011 (0.0072–0.025) |
||||
| K CHANNEL | |||||
| Kv1.x | Soma | 0.005 (0.004–0.007) |
-80 | HH | [47] |
| Kv3.4 | Soma | 0.149 (0.11–0.195) |
-80 | HH | [57,58] |
| Axon | 0.0091 (0.0021–0.010) |
||||
| Kv4.3 | Soma | 0.004 (0.0035–0.0085) |
-80 | HH | [59] |
| Kv7.x | AIS | 0.0002 (0.00022–0.0003) |
-80 | HH | [16,17,48] |
| Ca DEPENDENT K CHANNELS | |||||
| Kca1.1 | Apical Dendrites | 0.01 (0.008–0.014) |
Markovian | [46] | |
| Basal Dendrites | 0.012 (0.009–0.014) |
||||
| Soma | 0.017 (0.0145–0.019) |
||||
| AIS | 0.1 (0.09–0.12) |
||||
| Kca2.2 | Apical Dendrites | 0.0024 (0.0018–0.0045) |
-80 | Markovian | [16,17] |
| Basal Dendrites | 0.016 (0.015–0.019) |
||||
| Kca3.1 | Soma | 0.0101 (0.09–0.15) |
-80 | HH | [60] |
| CA CHANNEL | |||||
| Cav2.2 | Basal Dendrites | 0.0013 (0.00125–0.0019) |
137.5 | HH | [48] |
| Soma | 0.0087 (0.0078–0.0165) |
||||
| AIS | 0.0059 (0.0045–0.0075) |
||||
| Cav2.3 | Apical Dendrites | 0.0012 (0.0012–0.0017) |
137.5 | HH | [61] |
| Cav3.1 | Apical Dendrites | 3.69e-5 (3.6e-5–7.5e-5) |
137.5 | HH | [46] |
| Soma | 3.40e-5 (3e-5–9.5e-5) |
||||
| MIXED CATIONIC CHANNEL | |||||
| HCN1 | AIS | 0.00033 (0.0001–0.00038 |
-20 | HH | [16,17] |
| HCN2 | AIS | 0.0003 (0.0003–0.00035 |
-20 | HH | [16,17] |
| CALCIUM BUFFER (mM)–PUMPS DENSITY | mol/cm2 | ||||
| Ca Buffer | Apical Dendrites | 5*10–9 | Markovian | [46] | |
| Basal Dendrites | 2*10–9 | ||||
| Soma | 1*10–7 | ||||
| AIS | 1*10–8 | ||||
| Axon | 1*10–8 |