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. 2021 Jan 26;2(2):100204. doi: 10.1016/j.xcrm.2021.100204

Figure 2.

Figure 2

SARS-CoV-2-specific CD4+ T cell reactivities and their correlations with antibody production and CD8+ T cell reactivity

(A) RBD IgG serology is shown for all the convalescent COVID-19 donors (n = 99) of this cohort.

(B–E) Serology data of (A) are correlated with CD4+ T cell reactivities specific against all combined proteins (B), structural proteins S, M, and N (C), non-structural proteins nsp3, nsp4, nsp12, and nsp13 (D), and ORF8 and ORF3a (E).

(F–I) The total CD8+ T cell reactivity is correlated with the total CD4+ T cell reactivity (F) and the CD4+ T cell reactivity against structural proteins S, M, and N (G), non-structural proteins nsp3, nsp4, nsp12, and nsp13 (H), and ORF8 and ORF3a (I).

Empty and filled circles represent correlation between CD4+ T cell reactivity and serology or CD8+ T cell reactivity, respectively. All analyses were performed using Spearman correlation, and the p values shown were not corrected for multiple hypothesis testing.