Figure 1.

Distinct vascular T-cell phenotypes in the healthy and atherosclerotic mouse aortas. Overview of the 4 major T-cell phenotypes identified by single-cell RNA-sequencing with key gene expression, frequencies, and regulated pathways during atherosclerosis progression. Gene signatures were retrieved by differentially expressed genes among all leukocytes across several studies. Frequencies of clusters were retrieved by an analysis of the original data set (*),³⁹ or estimations based on the original publication (**).⁴⁶ CD indicates chow diet–consuming mice; CTL, cytotoxic T-cell–mediated apoptosis; HFD, high-fat diet–consuming mice; IFN-γ, interferon-gamma; and WD, Western diet–consuming mice. ***Regulated pathways between CD and WD-fed mice were retrieved from study by Winkels et al.³⁹ Schematics adapted from “Smart Servier Medical Art.”