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. 2021 Jan 25;5(1):011501. doi: 10.1063/5.0029860

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© 2021 Author(s).

2473-2877/2021/5(1)/011501/11

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 4. — (a) Transmission electron microscopy (TEM) was conducted on c(RGDfK)/Pep-22-DOX-LP, indicating the uniform size and morphology of dually modified liposomes. (b) Kaplan–Meier survival curve of glioma-bearing mice when treated with unmodified liposomes LP, liposomes functionalized with the peptide c(RGDfk)-LP or Pep-22-LP, and co-functionalized liposomes with both c(RGDfk)/Pep-22-LP showing that the combination imparts a lower intensity of localization to the liver as well as a greater intensity of localization to the tumor. Ex vivo excised (c) organs and (d) brains in mice with glioma after 24 h post-injection. Adapted with permission from Chen et al., ACS Appl. Mater. Interfaces 9(7), 5864–5873 (2017). Copyright 2017 American Chemical Society.