Figure 2.

Effects of curcumin (CMN) administered orally on the diabetic neuropathic painful behavior induced by streptozotocin (STZ). STZ (50 mg/kg) was intraperitoneally injected to induce diabetic neuropathy in rats. After 4 weeks, rats were treated orally with vehicle and either 10 mg/kg/day or 50 mg/kg/day of CMN for 4 consecutive weeks. One day after final drug administration, behavioral tests were performed to measure responses to mechanical (a), acetone-induced cold (b), thermal ((c) 42°C and (d) 50°C), and cold ((e) 10°C and (f) 4°C) stimuli (n = 10 animals per group, one-way ANOVA with Bonferroni post hoc). ^∗p < 0.05, ^∗∗p < 0.001, and ^∗∗∗p < 0.001 compared to the Ctr + Veh group. ^†p < 0.05, ^††p < 0.01, and ^†††p < 0.001 compared to the STZ + Veh group.