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. 2021 Jan 19;2021:8787231. doi: 10.1155/2021/8787231

Figure 5.

Figure 5

Immunohistochemistry for pJNK (red, pJNK antibody) expression in the neurons of the dorsal root ganglion (DRG) (green, NF200 antibody). Treatment of streptozotocin- (STZ-) induced diabetic neuropathic pain rats (STZ + CMN50) with 50 mg/kg/day of curcumin (CMN) for 4 consecutive weeks normalized pJNK expression in the neurons of the DRG. (a) Control group (Ctr + Veh, n = 4), (b) curcumin-treated control group (Ctr + CMN50, n = 4), (c) STZ-induced diabetic neuropathic pain rats (STZ + Veh, n = 4), and (d) curcumin-treated STZ-induced diabetic neuropathic pain rats (STZ + CMN50, n = 4). ∗∗∗p < 0.001 compared to the Ctr + Veh group; †††p < 0.001 compared to the STZ + Veh group.