Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of necroptotic signaling stimulated by emodin in human renal cancer cells. Emodin produces a large amount of ROS by affecting the mitochondrial electron transport chain. On the one hand, ROS can inhibit aerobic glycolysis to suppress tumor cell proliferation, and on the other hand, ROS induces cell necroptosis by activating JNK signaling to phosphorylate the death-executing protein MLKL.
