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. 2020 Dec 18;6(1):e863. doi: 10.1097/PR9.0000000000000863

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Illustration of typical imputed values for a subject in the treatment group that drops out of the trial after week 1 for different assumptions concerning the missingness mechanism: missing at random (MAR) and jump to reference (J2R). The black squares () are the observed means in the placebo group, and the open squares () are the observed means in the treatment group. The asterisks represent either observed (weeks 0 and 1) or imputed (weeks 3, 5, and 8) values for the subject who dropped out of the trial.

Inline graphic — Illustration of typical imputed values for a subject in the treatment group that drops out of the trial after week 1 for different assumptions concerning the missingness mechanism: missing at random (MAR) and jump to reference (J2R). The black squares () are the observed means in the placebo group, and the open squares () are the observed means in the treatment group. The asterisks represent either observed (weeks 0 and 1) or imputed (weeks 3, 5, and 8) values for the subject who dropped out of the trial.