TABLE 1.
Pretransplant demographic and clinical data
| Parameter | All (n = 441) | SCI (n = 137) | NMA (n = 304) | P | ||
|---|---|---|---|---|---|---|
| SC-B-TCMR (n = 102) | SC-TCMR (n = 15) | SC-MVI (n = 20) | ||||
| Recipient age at transplant (y) | 49 ± 0.6 | 49 ± 1 | 53 ± 3 | 50 ± 3 | 49 ± 1 | 0.35 |
| Donor age at transplant (y) | 38 ± 0.6 | 38 ± 1 | 41 ± 3 | 41 ± 3 | 38 ± 1 | 0.55 |
| Donor KDPI | 40 ± 1.5 | 38 ± 3 | 46 ± 9 | 41 ± 7 | 40 ± 2 | 0.68 |
| Sex (male/female) | 273/168 | 68/34 | 10/5 | 14/6 | 181/123 | 0.13 |
| Donor type (deceased/living) | 265/176 | 64/38 | 10/5 | 15/5 | 176/128 | 0.15 |
| Recipient race (Black/non-Black) | 234/207 | 54/48 | 10/5 | 10/10 | 160/144 | 0.79 |
| Cause of ESRD, n (%) | ||||||
| Glomerular | 147 (33) | 35 (34) | 6 (40) | 6 (30) | 100 (33) | 0.83 |
| Diabetes | 108 (25) | 21 (21) | 4 (27) | 6 (30) | 77 (25) | |
| Other | 186 (42) | 46 (45) | 5 (33) | 8 (40) | 127 (42) | |
| Pretransplant diabetes, n (%) | 148 (34) | 31 (30) | 5 (33) | 6 (30) | 106 (35) | 0.39 |
| Pretransplant hepatitis C, n (%) | 10 (2) | 3 (3) | 0 (0) | 0 (0) | 7 (2) | 0.80 |
| Repeat transplant, n (%) | 42 (10) | 10 (10) | 2 (13) | 4 (20) | 26 (9) | 0.30 |
| cPRA at transplanta | 17 ± 1.5 | 18 ± 3 | 22 ± 9 | 40 ± 10 | 16 ± 2 | 0.05 |
| PRA < 20%, n (%) | 335 (77) | 78 (77) | 11 (73) | 9 (47) | 237 (79) | 0.31 |
| PRA 20%–80%, n (%) | 54 (12) | 13 (13) | 2 (13) | 5 (26) | 34 (11) | |
| PRA > 80%, n (%) | 48 (11) | 11 (11) | 2 (13) | 5 (26) | 30 (10) | |
| HLA-A and -B mismatch | 2.8 ± 0.1 | 2.8 ± 0.1 | 2.8 ± 0.4 | 2.5 ± 0.4 | 2.8 ± 0.8 | 0.93 |
| HLA-DR and -DQ mismatch | 2.3 ± 0.1 | 2.5 ± 0.1 | 1.9 ± 0.5 | 2.2 ± 0.2 | 2.3 ± 0.1 | 0.50 |
acPRA data were available from 437 participants.
Comparison of pretransplant demographic and clinical data between groups. The first column shows data for the entire cohort. The P represent comparisons between the SCI group (n = 137) and the NMA group (n = 304) by Mann-Whitney U test (continuous variables) or chi-square/Fisher exact test (categorical variables). Non-normally distributed continuous variables are presented as mean ± SE.
cPRA, calculated panel reactive antibodies; ESRD, end-stage renal disease; KDPI, Kidney Donor Profile Index; NMA, no major surveillance abnormalities; PRA, panel reactive antibodies; SC-B-TCMR, subclinical borderline T cell-mediated rejection; SCI, subclinical inflammation; SC-MVI, subclinical microvascular injury; SC-TCMR, subclinical T cell-mediated rejection.