Table 2.
COVID-19 severity, hospitalization, and outcomes by trimester of infection in pregnant patients
| Characteristic | All pregnant patients N=240a |
Hospitalization status |
Trimester of SARS-CoV-2 infection |
|||||
|---|---|---|---|---|---|---|---|---|
| Not hospitalized for COVID-19 concern (n=216) | Hospitalized for COVID-19 concern (n=24)b | P value | First (n=38) | Second (n=67) | Third (n=135) | P value | ||
| Trimester of infectionc | <.001 | |||||||
| First | 38 (15.8) | 37 (17.1) | 1 (4.2) | |||||
| Second | 67 (27.9) | 62 (28.7) | 5 (20.8) | |||||
| Third | 135 (56.3) | 117 (54.2) | 18 (75.0) | |||||
| Symptomatic at first COVID-19 positive testc | .02 | <.001 | ||||||
| Asymptomatic | 55 (22.9) | 54 (25.0) | 1d (4.2) | 3 (7.9) | 3 (4.5) | 49 (36.3) | ||
| Symptomatic | 185 (77.1) | 162 (75.0) | 23 (95.8) | 35 (92.1) | 64 (95.5) | 86 (63.7) | ||
| Disease severity | <.001 | .28 | ||||||
| Mild | 218 (90.8) | 213 (98.6) | 5 (20.8) | 37 (97.4) | 62 (92.5) | 119 (88.2) | ||
| Severe | 18 (7.5) | 3e (1.4) | 15 (62.5) | 0 (0) | 4 (6.0) | 14 (10.4) | ||
| Critical | 4 (1.7) | 0 (0) | 4 (16.7) | 1 (2.6) | 1 (1.5) | 2 (1.5) | ||
| Outcomes | ||||||||
| Hospitalized for COVID-19 concern | 24 (10.0) | 1 (2.6) | 5 (7.5) | 18 (13.3) | .11 | |||
| Admitted to ICU | 8 (3.3) | 0 (0.0) | 8 (33.3) | 0 (0) | 1 (1.5) | 7 (5.2) | .74 | |
| Maternal death | 3 (1.3) | 0 (0.0) | 3 (12.5) | <.001 | 1 (2.6) | 1 (1.5) | 1 (0.7) | .64 |
| Final pregnancy outcomef | 158 (65.8) | 135 (62.5) | 23 (95.8) | .001 | 3 (7.9) | 27 (40.3) | 128 (94.8) | <.001 |
| COVID-19 at final outcomeg | 90 (57.0) | 78 (57.8) | 12 (52.1) | .62 | 2 (66.7) | 2 (7.4) | 86 (67.2) | <.001 |
| Recovered from COVID-19 at final outcome | 68 (43.0) | 57 (42.2) | 11 (47.8) | .62 | 1 (33.3) | 25 (92.6) | 42 (32.8) | <.001 |
Gray shading indicates cells with no data.
COVID-19, coronavirus disease 2019; ICU, intensive care unit; SARS-COV-2, severe acute respiratory syndrome coronavirus 2.
Lokken et al. COVID-19 disease and mortality in pregnancy. Am J Obstet Gynecol 2021.
Summarized as number (percentage) or median (interquartile range)
One patient was hospitalized and admitted to ICU twice several months apart
At the time of the first positive SARS-CoV-2 test
This patient was tested owing to a known exposure to COVID-19 and became symptomatic before hospitalization
All 3 patients had dyspnea but were not ultimately hospitalized
Includes 1 maternal death and 2 spontaneous abortions in pregnant patients with first-trimester SARS-CoV-2 infections
Includes pregnant patients with mild or severe or critical COVID-19 at the time of final pregnancy outcome.