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The safety evaluation of various formulations. (A) The scheme of safety assay. (B) The maximum tolerated dose (MTD) of various formulations in C57BL/6 mice. (C) Neutrophil levels of various groups after formulations administration. (D) Creatinine (CR) levels of various groups after administration. Data are shown as the mean ± SD, n = 3, ∗∗∗P < 0.001.
