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. 2020 Aug 13;11(1):258–270. doi: 10.1016/j.apsb.2020.08.001

Figure 6.

Figure 6

The safety profiles of various formulations at a tolerated dose on central nervous system assessed by hematoxylin and eosin (H&E) staining and immunofluorescence analysis. Pyknotic nuclei and eosinophilic necrosis were indicated by arrows in white and heteromorphic nuclei was indicated by arrows in green. Activated microglia (Iba1+) in red are shown in the middle panel. Doublecortin (DCX+), representing immature neurons, was stained in green. Neuron-specific nuclear antigens (Neun+), indicating mature neurons, were stained in red. Scar bar = 100 μm.