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. 2020 Aug 13;11(1):258–270. doi: 10.1016/j.apsb.2020.08.001

Figure 8.

Figure 8

Pharmacodynamics of various formulations in circulating tumor cells in a lung metastasis model. (A) Model establishment and treatment. (B) Representative images of lungs originated from mice in different groups. (C) Hematoxylin and eosin (H&E) staining corresponding to panel B. (D) The weight of lungs harvested from mice on Day 14 after injection of cancer cells. (E) Body weight changes with time. (F) The number of foci on lungs dissected from mice of different groups. (G) The survival curve and median survival time of different groups. In image B&C, a-Saline, b-Jevtana, c-Lipo SA-CTX 6 mg/kg, d-Lipo SA-CTX 30 mg/kg, e-Lipo GA-CTX 6 mg/kg, f-Lipo GA-CTX 30 mg/kg, g-Lipo DA-CTX 6 mg/kg, h-Lipo DA-CTX 30 mg/kg. Data are shown as the mean ± SD, n = 5, ∗∗P < 0.01, ∗∗∗P < 0.001. Scale bar = 100 μm.