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. 2020 Jun 24;11(1):156–180. doi: 10.1016/j.apsb.2020.06.003

Scheme 1.

Scheme 1

The synthesis of compounds 5ak. Reagents and conditions: (a) HCl/Et2O, overnight, r.t.; (b) (COCl)2, 160 °C, 2.5 h; (c) NaOH, H2O2, 70 °C, 0.8 h; (d) ammonium hydroxide, HOBt, EDCI, NMM, THF, overnight, r.t.; (e) benzaldehyde analogues, DMAC, PTSA, NaHSO3, 120 °C, 16–20 h.