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. 2020 Jun 24;11(1):156–180. doi: 10.1016/j.apsb.2020.06.003

Scheme 2.

Scheme 2

The synthesis of compounds 11ae. Reagents and conditions: (a) cyclopropanecarbonyl chloride, Et3N, DCM, 0–25 °C, 5 h; (b) HCl/MeOH, 0–25 °C, 4–6 h; (c) thionyl chloride, toluene, 80 °C, 10 h; (e) Et3N, DCM, 0–20 °C, 3–5 h; (f) 2-aminobenzamide analogues, DMAC, PTSA, NaHSO3, 120 °C, 16–20 h.