Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The synthesis of compounds 15a‒e. Reagents and conditions: (a) thionyl chloride, toluene, 80 °C, 6 h; (b) 1-(cyclopropylcarbonyl)piperazine hydrochloride, or 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine, Et3N, DCM, 0–20 °C, 6–8 h; (c) 2-aminobenzamide analogues, DMAC, PTSA, NaHSO3, 120 °C, 16–20 h.
