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. 2020 Jun 24;11(1):156–180. doi: 10.1016/j.apsb.2020.06.003

Scheme 4.

Scheme 4

The synthesis of compounds 19av. Reagents and conditions: (a) various dibromoalkanes, DMF, K2CO3, overnight, r.t.; (b) hydroxyl-substituted analogues, DMF, K2CO3, r.t., or 80 °C, 8 h; (c) 2-amino-4,6-dimethoxybenzamide, DMAC, PTSA, NaHSO3, 120 °C, 16–20 h.