Table 1.

Inhibition rates of compounds 5a‒k against PARP1 and BRD4.

No.	R1	R2		R3		Inhibition rate (1 μmol/L/10 μmol/L, %)a
						PARP1 (μmol/L)		BRD4 (μmol/L)
						1	10	1	10
5a	4,6-diOCH3	CONHCH3		–		4	25	1	36
5b	H	CONHCH3		–		0	15	0	22
5c	4,6-diOCH3	CONH2		–		0	2	1	18
5d	H	CONH2		–		0	1	2	19
5e	4,6-diOCH3			–		2	36	12	70
5f	H			–		0	29	12	55
5g	4,6-diOCH3	–				9	34	3	13
5h	H	–				3	10	0	11
5i	4,6-diOCH3	–				8	31	7	60
5j	H	–				7	28	6	26
5k	4,6-diOCH3	–				6	39	8	42

‒Not applicable.

^aEach compound was tested in duplicate, the average value was obtained.