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. 2021 Jan 20;6(1):42–52. doi: 10.1016/j.jacbts.2020.11.002

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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VT Induction and EADs in DM Mice

(A) Representative electrocardiogram trace showing induced ventricular tachycardia (VT). Arrows indicate the paced beats. (B) More diabetes mellitus (DM) mice had inducible VT. (C) Representative whole-cell patch-clamp recordings of ventricular action potentials from control (Ctrl) (black) and DM (red) cardiomyocytes showing an early afterdepolarization (EAD). The arrow indicates EAD. (D) More DM cardiomyocytes show EADs. (E) Optical mapping traces of triggered activities (arrows) under slow heart rate by atrioventricular node ablation (n = 2 of 3 DM hearts). (F) The representative activation maps show that EAD or polymorphic VT was caused by triggered activities (arrows). (B, D) The n value is indicated within the bars. ∗p < 0.05. Ant. = anterior wall; Post. = posterior wall; Vm = membrane potential.