Figure 3.

Long-Term ICV Leptin or MTII Infusion for 2 Weeks Increased Cardiac Substrate Oxidation, p-AMPK/AMPK Ratio, and Mitochondrial Efficiency in Rats With Myocardial Infarction

(A) Phosphorylated adenosine monophosphate–activated protein kinase (p-AMPK)/AMPK ratio, (B) phosphorylated mechanistic target of rapamycin (p-mTOR)/mTOR ratio, (C) glucose oxidation, (D) fatty acid oxidation, and (E) cardiac fiber mitochondria adenosine triphosphate (ATP)–linked respiration in hearts from rats with myocardial infarction treated with ICV vehicle, leptin, or MTII at the end of the second week of treatment. ∗p < 0.05 compared with the vehicle-treated group. Abbreviations as in Figure 1.