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. 2021 Jan 25;6(1):55–70. doi: 10.1016/j.jacbts.2020.11.007

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Long-Term ICV Leptin or MTII Infusion Increased Cardiomyocyte Contractility in Melanocortin-4 Receptor–Knockout Rats With Myocardial Infarction

(A) Representative curves of isolated cardiomyocyte sarcomere shortening, (B) baseline sarcomere length, (C) sarcomere shortening (index of cardiomyocyte contraction), (D) sarcomere shortening velocity (contraction velocity), (E) resting calcium signal, and (F) calcium transient in isolated cardiomyocytes from hearts of rats with myocardial infarction treated with ICV vehicle or leptin at the end of the second week of treatment and sham controls. ∗p < 0.05 compared with vehicle-treated group; ‡p < 0.05 compared with sham controls. Abbreviations as in Figure 1.