Table 1.

Blood Glucose, Tissue Weight, and Infarct Area in ICV Leptin–Treated, ICV MTII–Treated, and ICV Vehicle–Treated Rats 28 Days After Myocardial Infarction

	Blood Glucose (mg/dl)	Heart (g)	Heart/Tibia Length	Liver (g)	Lung (Wet, g)	Lung (Dry, g)	Infarcted Area (%)
Vehicle	80 ± 6	1.5 ± 0.1	0.33 ± 0.02	12.8 ± 0.4	1.94 ± 0.04	0.39 ± 0.01	29 ± 4
Leptin	76 ± 6	1.3 ± 0.1	0.27 ± 0.01∗	8.8 ± 1.2∗	1.56 ± 0.09∗	0.31 ± 0.02∗	30 ± 3
MTII	70 ± 3	1.6 ± 0.1	0.34 ± 0.01	10.9 ± 0.6∗	1.89 ± 0.06	0.38 ± 0.01	32 ± 4

Values are mean ± SEM obtained on day 28 of chronic ICV infusion.

ICV = intracerebroventricular; MTII = melanotan II.

^∗p < 0.05 compared with vehicle (n = 6 to 8 per group).