Table 3.
Proportion of patients at increased risk of fragility fracture and 10-year fracture probability, according to fracture risk criteria
| Parameter | n (%) | 10-year fracture probability without BMD, median (Q1, Q3), % | |
|---|---|---|---|
| Hip fracture | Major osteoporotic fracture | ||
| Number of patients with increased risk of fragility fracture | 2077 (100.0) | 7.2 (4.1, 11.9) | 16.6 (11.5, 23.9) |
| Meeting 1 of the 3 criteria | |||
| Prior fracture only | 168 (8.1) | 4.4 (3.3, 5.6) | 16.2 (12.7, 17.9) |
| FRAX threshold only | 733 (35.3) | 11.5 (8.9, 15.8) | 21.1 (17.6, 25.8) |
| T-score onlya | 83 (4.0) | 5.8 (4.1, 7.7) | 13.6 (11.0, 16.5) |
| Meeting 2 of the 3 criteria | |||
| Prior fracture and FRAX threshold | 858 (41.3) | 12.3 (8.7, 17.4) | 26.7 (21.9, 32.3) |
| Prior fracture and T-score | 12 (0.6) | 5.4 (4.0, 5.9) | 17.7 (16.4, 18.8) |
| FRAX threshold and T-score | 61 (2.9) | 13.9 (11.8, 18.9) | 23.2 (21.1, 27.6) |
| Meeting all 3 criteria | 162 (7.8) | 14.2 (10.7, 24.0) | 30.6 (25.1, 39.1) |
BMD, bone mineral density; FRAX, Fracture Risk Assessment Tool; Q, quartile
aBMD results were only available in subset (24.9%) of the cohort
A patient was considered to be at increased risk of fragility fracture if ≥ 1 of the 3 following criteria were met: (1) had a history of fracture; (2) 10-year probability of hip fracture without BMD > country-specific threshold and 10-year probability of major osteoporotic fracture without BMD > country-specific threshold; (3) BMD T-score ≤ − 2.5 for any of lumbar spine/total hip/femoral neck
Groups are mutually exclusive (i.e., patients are only counted once with respect to how they met the criteria)
Percentages based on number of patients enrolled who are at increased risk of fragility fracture using the base definition