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. 2021 Jan 26;11:2275. doi: 10.1038/s41598-021-81768-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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3.5-month treatment with liraglutide, 7,8-DHF or with their combination delayed the progression of optic nerve atrophy in Wfs1 KO animals. Electron micrographs representing cross-sections from analyzed (a–d) WT and (e–h) Wfs1 KO rat’s optic nerves from corresponding treatments, liraglutide (LIRA), 7,8-DHF (DHF) or liraglutide and 7,8-DHF (LIRA + DHF). (i) Optic nerve axon size distribution in every treatment group, (j) average axon area per field of view (FOV), (k) average myelin area per FOV, (l) G-ratios calculated as total axonal area divided by total axonal area plus myelin area. Quantitative data were compared using factorial ANOVA followed by Fisher’s LSD tests; *p < 0.05; ***p < 0.001 compared to WT vehicle animals and # p < 0.05 compared to KO Sal animals. The data are presented as the mean ± SEM, n = 4–7 per group. Scale bar: 2 μm.