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. 2021 Jan 26;11:2279. doi: 10.1038/s41598-021-81940-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Miami plot of the GWASs for model 1 (MHNW versus MUHNW) and model 2 (MHO versus MUHO). SNP locations are plotted on the x-axis according to their chromosomal position. The −log₁₀(p-values) derived from the logistic regression analysis are plotted on the y-axis. The p-values were adjusted for age, sex, exercise status, smoking status, alcohol intake, body mass index, and PC1 and PC2. The horizontal red line indicates the formal threshold for genome-wide significance at p = 5.00 × 10⁻⁸. GWASs, genome-wide association studies; MHNW, metabolically healthy normal weight; MUHNW, metabolically unhealthy normal weight; MHO, metabolically healthy obese; MUHO, metabolically unhealthy obese; PC, principle component; SNP, single-nucleotide polymorphism. The figure was generated using EasyStrata version 8.6 (http://www.genepi-regensburg.de/easystrata).