Table 3.

Motor cortical function on TMS (mean ± SD).

	Controls n = 30	ALS n = 39	ALS-Cog n = 10	ALS-FTD n = 12	p-value	Post hoc test
Resting motor threshold (RMT)	64.3 ± 12.6	60.8 ± 13.9	63.3 ± 12.7	50.2 ± 6.9	0.015	ALS-FTD < HCb
Average SICI	11.3 ± 6	5.1 ± 9.2	− 1.5 ± 7.8	3.1 ± 8.6	< 0.001	ALS < HCa ALS-Cog < HCc ALS-FTD < HCa
Peak SICI	19.2 ± 8.8	13.6 ± 10.8	8.4 ± 7.6	10.5 ± 6.9	0.005	ALS-Cog < HCa
Average ICF	− 3.8 ± 9	− 1.1 ± 7.5	− 2 ± 7.6	0.3 ± 13.5	0.147	NA
CSP	181.7 ± 52.4	186.9 ± 39.9	168.1 ± 38.6	186.1 ± 45.9	0.659	NA
MEP amplitude	2.1 ± 1.9	2.5 ± 1.9	2.7 ± 1.9	3.3 ± 2.1	0.475	NA

Distribution of motor cortical function across the ALS phenotypes is shown.

SICI, short interval intracortical inhibition; ICF, intracortical facilitation; MEP, motor evoked potential; HC, healthy controls.

^a0.01 < p < 0.05; ^b 0.001 < p < 0.01; ^c p < 0.001, NA = not applicable.