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. 2021 Jan 26;11:2216. doi: 10.1038/s41598-021-81183-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Levels of pro-inflammatory mediators; (A) serum level of IL-6 (pg/ml) and (B) gastric level of NO (μM of nitrite/g tissue). (C) Immunostaining of TNF-α in rats’ gastric tissues (X: 100). (a) N group, (b) ulcer group, (c) ome group, (d) plain group, (e) ALL group, (f) NanoAL group, and (g) NanoAH group. X: 100. Data are expressed as mean ± SEM, ^#p < 0.001 compared to N group, **p < 0.01 compared to ulcer group ***p < 0.001 compared to ulcer group, ^@p < 0.01 compared to Ome group, ^$p < 0.001 compared to ALL group, ^Ap < 0.01 compared to plain group, ^%p < 0.001 compared to NanoAL group using GraphPad Prism 5.00 (http://www.graphpad.com). Positive stainings are shown by yellow arrow.