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ICPs and levels of a 24 full factorial design.
| ICPs | Maximum coded level | Minimum coded level | Maximum level | Minimum level |
|---|---|---|---|---|
| (X1) CS concentration (%, w/v) | + 1 | − 1 | 1.5 | 1 |
| (X2) STPP concentration (%, w/v) | + 1 | − 1 | 0.5 | 0.3 |
| (X3) CS:STPP volume ratio | + 1 | − 1 | 5:1 | 3:1 |
| (X4) ALL amount (mg) | + 1 | − 1 | 13 | 10 |
