Table 3.
Kinetic analysis of the percentage drug released and that diffused from ALL-loaded CS/STPP NPs (F-9) and pure ALL, respectively (see Table 2 for F-9).
| Formula | Coefficients of determination (R2) | Korsmeyer-Peppas | Weibull | |||||
|---|---|---|---|---|---|---|---|---|
| Zero-order | First-order | Higuchi model | (R2) | Diffusional exponent (n) | Main transport mechanism | (R2) | β | |
| F-9 (pH 1.2) | 0.9539 | 0.9484 | 0.9670 | 0.9316 | 0.4473 | Fickian | 0.9464 | 0.5586 |
| F-9 (pH 6.8) | 0.7197 | 0.7585 | 0.8717 | 0.9604 | 0.2284 | Fickian | 0.9621 | 0.2495 |
| F-9 (pH 7.4) | 0.6453 | 0.6942 | 0.8271 | 0.9340 | 0.2238 | Fickian | 0.9418 | 0.2502 |
| Free drug (pH 1.2) | 0.9824 | 0.8250 | 0.9501 | 0.9354 | 0.4746 | Fickian | – | – |
| Free drug (pH 6.8) | 0.8665 | 0.8848 | 0.9888 | 0.9968 | 0.4820 | Fickian | – | – |
| Free drug (pH 7.4) | 0.8913 | 0.8055 | 0.9983 | 0.9990 | 0.4905 | Fickian | – | – |