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. 2021 Jan 26;11:2191. doi: 10.1038/s41598-021-81726-2

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© The Author(s) 2021, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SAMiRNA-AREG ameliorated renal fibrosis in the AD-induced model. (a) Time scheme for SAMiRNA-AREG efficacy analysis in AD mice. (b) Histological analysis by H&E, MT, and IHC staining of control, UUO, or SAMiRNA-AREG-treated AD mice. Tubular dilatation, fibrosis areas, and α-SMA-positive areas were quantified. Scale bar, 100 μm. (c) AREG proteins in kidney tissue lysates were measured by ELISA. The numbers indicate the mean value of each data set. (d,e) BUN and serum creatinine were measured by ELISA. (f) Kidney tissue lysates were subjected to real-time qRT-PCR analysis for AREG, fibronectin, α1(I) collagen, and α1(III) collagen (mean ± SEM). *p < 0.05, **p < 0.01, ***p < 0.001 compared with AD mice by ANOVA with the Newman-Keuls post-hoc test.