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SAMiRNA-AREG inhibited EGFR phosphorylation by downregulating AREG in UUO- or AD-induced renal fibrosis. (a,b) Representative images of AREG expression and EGFR phosphorylation revealed overexpression in the UUO- or AD-induced models of renal fibrosis, which was attenuated by SAMiRNA-AREG administration (1 mg/kg or 5 mg/kg). The AREG- and p-EGFR-positive areas were quantified. Scale bar, 100 μm. ***p < 0.001 compared to UUO or AD mice by ANOVA with the Newman-Keuls post-hoc test.
